Not many organizations can claim to have saved a billion lives. But CGIAR’s crop breeding work has been credited with doing just that. Its research catalyzed the Green Revolution by developing high-yielding wheat and rice varieties, mostly for Asia, where starvation loomed. But today’s challenges cannot be overcome using the same approaches that delivered those life-saving varieties. Poverty, food and nutrition needs, environmental degradation, and climate change are pressing our food systems like never before — especially in lower- and middle-income countries. Major climate change impacts are hitting agriculture faster than we expected and will only worsen.